REVEALING THE MECHANISMS OF PROTEIN DISORDER AND N-GLYCOSYLATION IN CD44-HYALURONAN BINDING USING MOLECULAR SIMULATION

Revealing the mechanisms of protein disorder and N-glycosylation in CD44-hyaluronan binding using molecular simulation

The extracellular N-terminal hyaluronan binding domain (HABD) of CD44 is a small globular domain that confers hyaluronan (HA) binding functionality to this large transmembrane glycoprotein.When recombinantly expressed by itself, HABD exists as a globular water-soluble protein that retains the capacity to bind HA.This has enabled atomic-resolution s

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Dynamic Rock-Breaking Process of TBM Disc Cutters and Response Mechanism of Rock Mass Based on Discrete Element

Rock-breaking efficiency of full-face rock tunnel boring machine (TBM) is closely related to the performance of the disc cutter and the characteristics of the rock mass.In the point of view of mesomechanics, the particle flow code (PFC) is used to establish a numerical model of the rock mass and the disc cutter, and the process of TBM disc cutter i

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